Leading the way in experimental and clinical research in hematology. PAR1 biased signaling is required for activated protein C in vivo benefits in sepsis and stroke.

The eLearning platform for hematologists. On-demand viewing of ASH educational meetings and webinars. Educational Web-based library of hematologic imagery. Resources to help practitioners improve patient care.

We explore the gene expression profiles of parvoviruses. And study the molecular mechanisms underlying DNA replication and pathogenesis of parvoviruses. We apply parvovirus as a model system to understand the basic cellular processes of pre-mRNA processing and DNA damage signaling, and as a viral vector for gene therapy in the Department of Microbiology. Last updated on December 23, 2017.

A European collaborative study of cyclophosphamide, bortezomib, and dexamethasone in upfront treatment of systemic AL amyloidosis. Promising therapies in multiple myeloma.

Platelet function tests, independent of platelet count, are associated with bleeding severity in ITP. Frelinger III, Rachael F. Berny-Lang, Travis Brown, Sabrina L. Eradication of B-ALL using chimeric antigen receptor expressing T cells targeting the TSLPR oncoprotein.

Chronic transfusion therapy improves but does not normalize systemic and pulmonary vasculopathy in sickle cell disease. The LSD1 inhibitor RN-1 induces fetal hemoglobin synthesis and reduces disease pathology in sickle cell mice. Circulating cell membrane microparticles transfer heme to endothelial cells and trigger vasoocclusions in sickle cell disease.

Platelet function tests, independent of platelet count, are associated with bleeding severity in ITP. Frelinger III, Rachael F. Berny-Lang, Travis Brown, Sabrina L. Persistent neonatal thrombocytopenia can be caused by IgA antiplatelet antibodies in breast milk of immune thrombocytopenic mothers.